Savene® (dexrazoxane) has a unique dual mechanism of action: 1/ Inhibition of DNA topoisomerase II
Savene® inhibits DNA topoisomerase II, the target of anthracycline chemotherapy. Savene® binds to DNA topoisomerase II at a different step in the catalytic cycle than anthracyclines. This locks the enzyme in a form that is no longer affected by anthracyclines.
Topoisomerase II catalytic cycle (adapted from Andoh & Ishida, 1998, with permission)