Patient Information


 

What SAVENE® is used for

 

When anthracycline anti-cancer drugs accidentally leak from the blood vessel into the surrounding tissue, they can cause acute local symptoms such as swelling and/or redness and pain. It may also cause serious destruction of the skin, the subcutaneous tissues, and muscles.4 In the worst cases an extensive surgical procedure has to be performed and the wound covered by a skin graft transplant. This event is called extravasation. SAVENE® is used as an antidote to treat extravasations caused by the group of anti-cancer medicines called anthracyclines.1

 

How SAVENE® is used

 

SAVENE® will be given by infusion into a vein. The infusion will last 1-2 hours and you will receive a total of 3 infusions. The first infusion will be given as soon as possible after the accident. The subsequent infusions will be given 24 and 48 hours later, respectively. You will be closely monitored by doctors and nurses during the 3-day treatment period. The dose you will receive will depend on your height and weight. Your doctor will calculate your body surface area in square meters (m2) and will determine the appropriate dose. If you have any further questions on the use of this product, ask your doctor.

 

Special care with SAVENE®

 

SAVENE® should only be given to you if you have experienced an extravasation in connection with anthracycline-containing chemotherapy. In the days after treatment with SAVENE® you will have blood tests taken regularly to check your blood cell count.
Special care with SAVENE® is needed if you receive phenytoin (anti-epileptic medicines) or live attenuated vaccines. The use of an inactivated vaccine where this exists (e.g. poliomyelitis) is recommended. If you have liver dysfunction your doctor will monitor your liver function during treatment. If you have kidney dysfunction your doctor will monitor for signs of changes to your blood cells.
SAVENE® has not been tested in the treatment of extravasation in children and therefore cannot be recommended for use in the paediatric population. Men being treated with dexrazoxane (the active ingredient of SAVENE®) are advised not to father a child during and up to three months after treatment. Women of childbearing potential must use contraceptive measures during treatment.

 

Taking other medicines

 

SAVENE® should not be mixed with any other medicines during the infusion. It is not advisable to use any medical treatment without telling your doctor as there may be interactions between SAVENE® and other medicines. Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

 

SAVENE® will not be used:

 

If you are allergic (hypersensitive) to dexrazoxane or any of the other ingredients of SAVENE®, if you are planning to become pregnant and do not use adequate contraceptive measures, if you are breast-feeding or if you are given yellow fever vaccine.1

 

Possible side effects:

 

Like all medicines, SAVENE® can cause side effects, although not everybody gets them. The precautions to be taken are the same as when you receive your usual chemotherapy, namely to contact the doctor if you notice any side effects.