SAVENE® (dexrazoxane) has a unique dual mechanism of action: 1/ Inhibition of DNA topoisomerase II

SAVENE® inhibits DNA topoisomerase II, the target of anthracycline chemotherapy.
SAVENE® binds to DNA topoisomerase II at a different step in the catalytic cycle than anthracyclines.1,12 This locks the enzyme in a form that is no longer affected by anthracyclines.


Topoisomerase II catalytic cycle (adapted from Andoh & Ishida, 1998, with permission)13